Nicotinamide Riboside (NR)
Pathway Genes
Biomeme does not prescribe, supply, recommend or evaluate this therapy. This page describes which genes it acts on, not whether you should take it.
Nicotinamide riboside is an NAD+ precursor taken up by cells and phosphorylated by the nicotinamide riboside kinases NMRK1 and NMRK2. This page describes those genes and what a transcript panel can and cannot say about them.
Tracked Physiological Dimensions
On the Advanced Transcriptomics Dashboard, nicotinamide riboside is tracked across two key bioenergetic dimensions.
Nicotinamide Riboside Kinase Gene Regulation
Nicotinamide riboside enters cells and is converted to NMN by the nicotinamide riboside kinases NMRK1 and NMRK2. Precursor availability affects downstream enzyme activity rather than directly commanding transcript abundance.
This panel reports the transcription of NMRK1, NMRK2, SIRT3 and COX4I1.
Key Target Genes
Nicotinamide Riboside Kinases 1 & 2 Direct NR Import
Phosphorylate nicotinamide riboside into NMN.
Sirtuin 3 (Mitochondrial) Mitochondrial Health
Mitochondrial NAD+-dependent deacetylase regulating respiratory enzymes.
Cytochrome c Oxidase Subunit 4I1 Electron Transport Chain
Terminal subunit of cytochrome c oxidase (Complex IV) in the mitochondrial electron transport chain.
Nicotinamide Phosphoribosyltransferase Salvage Pathway Independence
Rate-limiting salvage enzyme that recycles nicotinamide into NMN.
The Biomeme Molecular Ecosystem
From deep whole-transcriptome sequencing in the laboratory to rapid point-of-care instrumentation in the field.
High-Depth RNA Sequencing
Processed at One Health Labs, Biomeme's CLIA-certified laboratory, using Illumina NovaSeq high-depth paired-end RNA sequencing. Samples are collected in venous PAXgene blood RNA tubes to stabilize cellular transcription at the moment of draw.
Biomeme/5 Handheld Platform
Beyond central-lab genomics, Biomeme engineers patented, battery-powered real-time PCR instruments. Our deployable hardware brings decentralized molecular detection directly to the field and clinical points of care.
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ABOUT THESE PANELS
Biomeme's wellness transcriptomic panels are general wellness products. They report gene activity to support a healthy lifestyle. They are not intended to diagnose, treat, cure, mitigate or prevent any disease or condition, and they are not a substitute for evaluation by a licensed healthcare professional. Results describe the state of the measured transcripts at the moment the sample was taken.