MOTS-c
Pathway Genes
Biomeme does not prescribe, supply, recommend or evaluate this therapy. This page describes which genes it acts on, not whether you should take it.
There are no published human clinical trials of this peptide.
MOTS-c is a mitochondrial-derived peptide studied in preclinical models of metabolic regulation. This page describes the genes those studies implicate and what a transcript panel can and cannot say about them.
Tracked Physiological Dimensions
On the Advanced Transcriptomics Dashboard, MOTS-c is tracked across two key bioenergetic dimensions.
Mitochondrial and Metabolic Gene Regulation
In preclinical models, MOTS-c has been associated with AMPK phosphorylation and changes in metabolic gene expression.
This panel reports the transcription of PRKAA1, SLC2A4 and PPARGC1A.
Key Target Genes
AMP-Activated Protein Kinase Energy Regulation
Kinase that responds to energy stress. It is activated by nucleotide binding and phosphorylation, so its transcript level does not report its activation state (PMID 22436748).
Glucose Transporter Type 4 Glucose Transport
Facilitative glucose transporter mobilised to the cell membrane from a pre-existing vesicle pool (PMID 31175156).
PGC-1α Mitochondrial Biogenesis
Coordinates the transcription of mitochondrial DNA and respiration machinery.
Carnitine Palmitoyltransferase 1B Fatty Acid Oxidation
Rate-limiting enzyme for mitochondrial fatty acid beta-oxidation in muscle (PMID 31900483).
The Biomeme Molecular Ecosystem
From deep whole-transcriptome sequencing in the laboratory to rapid point-of-care instrumentation in the field.
High-Depth RNA Sequencing
Processed at One Health Labs, Biomeme's CLIA-certified laboratory, using Illumina NovaSeq high-depth paired-end RNA sequencing. Samples are collected in venous PAXgene blood RNA tubes to stabilize cellular transcription at the moment of draw.
Biomeme/5 Handheld Platform
Beyond central-lab genomics, Biomeme engineers patented, battery-powered real-time PCR instruments. Our deployable hardware brings decentralized molecular detection directly to the field and clinical points of care.
Scientific Citations (3)
- [1] Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol. 2012;13(4):251-262.
- [2] Klip A, McGraw TE, James DE. Thirty sweet years of GLUT4. J Biol Chem. 2019;294(30):11369-11381.
- [3] Schlaepfer IR, Joshi M. CPT1A-mediated Fat Oxidation, Mechanisms, and Therapeutic Potential. Endocrinology. 2020;161(2):bqz046.
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ABOUT THESE PANELS
Biomeme's wellness transcriptomic panels are general wellness products. They report gene activity to support a healthy lifestyle. They are not intended to diagnose, treat, cure, mitigate or prevent any disease or condition, and they are not a substitute for evaluation by a licensed healthcare professional. Results describe the state of the measured transcripts at the moment the sample was taken.