Epitalon
Pathway Genes
Biomeme does not prescribe, supply, recommend or evaluate this therapy. This page describes which genes it acts on, not whether you should take it.
There are no published human clinical trials of this peptide.
Epitalon is a synthetic tetrapeptide studied in relation to telomere biology. This page describes the genes involved and what a transcript panel can and cannot say about them.
Tracked Physiological Dimensions
On the Advanced Transcriptomics Dashboard, Epitalon is tracked across the cellular aging dimension.
Telomerase and Senescence Gene Regulation
Epitalon is a synthetic tetrapeptide originally described as a pineal gland extract fraction. It has been studied in relation to telomere biology and cell cycle regulation.
This panel reports the transcription of TERT, SIRT1, CDKN2A and MAP1LC3B. Two limits are worth knowing before reading a result. TERT transcript does not track telomerase activity, which also requires the TERC RNA component and assembly of the holoenzyme (PMID 10220433). And autophagy-gene transcript levels are a poor proxy for autophagic flux, which is measured by LC3-II protein turnover rather than by mRNA (PMID 20144757).
Key Target Genes
Telomerase Reverse Transcriptase Telomere Maintenance
Catalytic protein subunit of telomerase, the reverse transcriptase that adds telomeric repeats to chromosome ends. Transcriptionally restricted in most somatic cells.
Sirtuin 1 Epigenetic Silencing & Repair
NAD+-dependent deacetylase that removes acetyl groups from histones and other substrates, linking cellular NAD+ availability to chromatin state and metabolic regulation.
Cell Cycle Arrest Marker Cellular Senescence
Cell-cycle-arrest transcript associated with cellular senescence.
Autophagy Indicator Lysosomal Clearance
Autophagy-related protein incorporated into the autophagosome membrane as it forms, and the standard marker used to identify autophagosomes.
The Biomeme Molecular Ecosystem
From deep whole-transcriptome sequencing in the laboratory to rapid point-of-care instrumentation in the field.
High-Depth RNA Sequencing
Processed at One Health Labs, Biomeme's CLIA-certified laboratory, using Illumina NovaSeq high-depth paired-end RNA sequencing. Samples are collected in venous PAXgene blood RNA tubes to stabilize cellular transcription at the moment of draw.
Biomeme/5 Handheld Platform
Beyond central-lab genomics, Biomeme engineers patented, battery-powered real-time PCR instruments. Our deployable hardware brings decentralized molecular detection directly to the field and clinical points of care.
Scientific Citations (2)
- [1] Liu K, Schoonmaker MM, Levine BL, June CH, Hodes RJ, Weng NP. Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes. Proc Natl Acad Sci U S A. 1999;96(9):5147-5152.
- [2] Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell. 2010;140(3):313-326.
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ABOUT THESE PANELS
Biomeme's wellness transcriptomic panels are general wellness products. They report gene activity to support a healthy lifestyle. They are not intended to diagnose, treat, cure, mitigate or prevent any disease or condition, and they are not a substitute for evaluation by a licensed healthcare professional. Results describe the state of the measured transcripts at the moment the sample was taken.